4-Tetrafluoro-O-Toluoyl Chloride

4-Tetrafluoro-O-Toluoyl Chloride - Names and Identifiers

Name	4-fluoro-2-(trifluoromethyl)benzoyl chloride
Synonyms	4-Tetrafluoro-O-Toluoyl Chloride à,à,à,4-tetrafluoro-o-toluoyl chloride 2-(Chlorocarbonyl)-5-fluorobenzotrifluoride 4-FLUORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 4-fluoro-2-(trifluoromethyl)benzoyl chloride alpha,alpha,alpha,4-Tetrafluoro-o-toluoyl chloride
CAS	189807-21-4
InChI	InChI=1/C8H3ClF4O/c9-7(14)5-2-1-4(10)3-6(5)8(11,12)13/h1-3H

4-Tetrafluoro-O-Toluoyl Chloride - Physico-chemical Properties

Molecular Formula	C8H3ClF4O
Molar Mass	226.56
Density	1.495 g/mL at 25 °C (lit.)
Boling Point	157 °C (lit.)
Flash Point	185°F
Water Solubility	Not miscible in water.
Vapor Presure	0.267mmHg at 25°C
Appearance	Liquid
Color	Clear colorless to yellow
Storage Condition	2-8°C
Sensitive	Moisture Sensitive
Refractive Index	n20/D 1.468(lit.)
MDL	MFCD00061158

4-Tetrafluoro-O-Toluoyl Chloride - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3265 8/PG 2
WGK Germany	3
HS Code	29163990
Hazard Note	Corrosive
Hazard Class	8
Packing Group	II

4-Tetrafluoro-O-Toluoyl Chloride - Introduction

Nature:
4-fluoro-2-(trifluoromethyl)benzoyl chloride is a colorless liquid with a pungent odor. It has a high melting point and boiling point, and can be dissolved in a variety of organic solvents such as ethanol and chloroform. This compound is a powerful acylating agent and can react with alcohols, amines and acids to give the corresponding esters, amides and acid derivatives.

Use:
4-fluoro-2-(trifluoromethyl)benzoyl chloride has a wide range of applications in the field of organic synthesis. It is usually used as a reagent for the acyl chloride reaction in organic synthesis. The acyl chloride reaction is a type of reaction commonly used in organic synthesis, which is used to introduce acyl groups (functional groups with acyl groups) into molecules to build complex organic compounds.

Method:
4-fluoro-2-(trifluoromethyl)benzoyl chloride can be prepared by the reaction of 2-(trifluoromethyl) benzoic acid and thionyl chloride under certain temperature conditions. The reaction is usually carried out under an inert atmosphere to prevent reaction with water and oxygen in the air.

Safety Information:
4-fluoro-2-(trifluoromethyl)benzoyl chloride is an irritating compound and care should be taken to avoid contact with the skin, eyes, and respiratory tract. Appropriate personal protective equipment such as gloves, goggles and respiratory protection equipment should be used during operation. Its use and storage should be carried out in a well-ventilated place and away from flammable and oxide.

It should be noted that the above information is for reference only. Please operate carefully according to the specific situation in actual applications and follow relevant safety regulations.

Last Update：2024-04-09 15:17:54